Open Access

Effects of DNA methylation and its application in inflammatory bowel disease (Review)

  • Authors:
    • Francis Atim Akanyibah
    • Yi Zhu
    • Aijun Wan
    • Dickson Kofi Wiredu Ocansey
    • Yuxuan Xia
    • An-Ning Fang
    • Fei Mao
  • View Affiliations

  • Published online on: April 30, 2024     https://doi.org/10.3892/ijmm.2024.5379
  • Article Number: 55
  • Copyright: © Akanyibah et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Inflammatory bowel disease (IBD) is marked by persistent inflammation, and its development and progression are linked to environmental, genetic, immune system and gut microbial factors. DNA methylation (DNAm), as one of the protein modifications, is a crucial epigenetic process used by cells to control gene transcription. DNAm is one of the most common areas that has drawn increasing attention recently, with studies revealing that the interleukin (IL)‑23/IL‑12, wingless‑related integration site, IL‑6‑associated signal transducer and activator of transcription 3, suppressor of cytokine signaling 3 and apoptosis signaling pathways are involved in DNAm and in the pathogenesis of IBD. It has emerged that DNAm‑associated genes are involved in perpetuating the persistent inflammation that characterizes a number of diseases, including IBD, providing a novel therapeutic strategy for exploring their treatment. The present review discusses DNAm‑associated genes in the pathogenesis of IBD and summarizes their application as possible diagnostic, prognostic and therapeutic biomarkers in IBD. This may provide a reference for the particular form of IBD and its related methylation genes, aiding in clinical decision‑making and encouraging therapeutic alternatives. 
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June-2024
Volume 53 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Akanyibah FA, Zhu Y, Wan A, Ocansey DK, Xia Y, Fang A and Mao F: Effects of DNA methylation and its application in inflammatory bowel disease (Review). Int J Mol Med 53: 55, 2024
APA
Akanyibah, F.A., Zhu, Y., Wan, A., Ocansey, D.K., Xia, Y., Fang, A., & Mao, F. (2024). Effects of DNA methylation and its application in inflammatory bowel disease (Review). International Journal of Molecular Medicine, 53, 55. https://doi.org/10.3892/ijmm.2024.5379
MLA
Akanyibah, F. A., Zhu, Y., Wan, A., Ocansey, D. K., Xia, Y., Fang, A., Mao, F."Effects of DNA methylation and its application in inflammatory bowel disease (Review)". International Journal of Molecular Medicine 53.6 (2024): 55.
Chicago
Akanyibah, F. A., Zhu, Y., Wan, A., Ocansey, D. K., Xia, Y., Fang, A., Mao, F."Effects of DNA methylation and its application in inflammatory bowel disease (Review)". International Journal of Molecular Medicine 53, no. 6 (2024): 55. https://doi.org/10.3892/ijmm.2024.5379