Open Access

Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review)

  • Authors:
    • You-Fan Peng
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  • Published online on: December 21, 2023     https://doi.org/10.3892/mi.2023.128
  • Article Number: 4
  • Copyright : © Peng . This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The dual burden of pulmonary tuberculosis (PTB) and diabetes mellitus (DM) is a major global public health concern. There is increasing evidence to indicate an association between PTB and DM. DM is associated with immune dysfunction and altered immune components. Hyperglycemia weakens the innate immune response by affecting the function of macrophages, dendritic cells, neutrophils, and natural killer cells, and also disrupts the adaptive immune response, thus promoting the susceptibility of PTB in patients with DM. Antituberculosis drugs often cause the impairment of liver and kidney function in patients with PTB, and the infection with Mycobacterium tuberculosis weaken pancreatic endocrine function by causing islet cell amyloidosis, which disrupts glucose metabolism and thus increases the risk of developing DM in patients with PTB. The present review discusses the association between PTB and DM from the perspective of epidemiology, pathogenesis, and treatment management. The present review aims to provide information for the rational formulation of treatment strategies for patients with PTB‑DM.
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January-February 2024
Volume 4 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Peng Y: Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review). Med Int 4: 4, 2024
APA
Peng, Y. (2024). Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review). Medicine International, 4, 4. https://doi.org/10.3892/mi.2023.128
MLA
Peng, Y."Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review)". Medicine International 4.1 (2024): 4.
Chicago
Peng, Y."Pulmonary tuberculosis and diabetes mellitus: Epidemiology, pathogenesis and therapeutic management (Review)". Medicine International 4, no. 1 (2024): 4. https://doi.org/10.3892/mi.2023.128