Open Access

Severe hepatitis E virus genotype 3b in a patient with alcohol‑associated liver disease: A case report

  • Authors:
    • Tatsuo Kanda
    • Shuhei Arima
    • Reina Sasaki‑Tanaka
    • Mai Totsuka
    • Masayuki Honda
    • Ryota Masuzaki
    • Naoki Matsumoto
    • Masahiro Ogawa
    • Masaharu Takahashi
    • Hiroaki Okamoto
    • Hirofumi Kogure
  • View Affiliations

  • Published online on: March 7, 2024     https://doi.org/10.3892/mi.2024.146
  • Article Number: 22
  • Copyright : © Kanda et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Hepatitis E virus (HEV) infection occasionally causes acute‑on‑chronic liver failure in patients with alcohol‑associated cirrhosis. These reports have been published mainly from highly HEV genotype 1‑endemic countries. The present study describes the case of a patient with severe HEV genotype 3b infection and alcohol‑associated liver disease. A male patient in his 70s who consumed alcohol, and who had begun consuming alcohol at the age of 12, had high levels of alanine aminotransferase (ALT) and total bilirubin. The peak levels of ALT and total bilirubin were 1,067 IU/l and 26.3 mg/dl, respectively. A computed tomography scan revealed an atrophic liver. Upon admission, both anti‑HEV immunoglobulin A and HEV RNA were positive, and his HEV was genotype 3b. He also had chronic kidney disease, as his estimated glomerular filtration rate was <45 ml/min/1.73 m2, and ribavirin could not be used. The abnormal levels of the liver function parameters of the patient gradually improved due to conservative treatment, and he was discharged on day 43. On the whole, the present study demonstrates that careful attention should be paid to patients with viral hepatitis, including hepatitis E, when alcohol‑associated liver disease is present. Novel anti‑HEV drugs need to be developed for severe HEV infections with chronic kidney disease.
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May-June 2024
Volume 4 Issue 3

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Spandidos Publications style
Kanda T, Arima S, Sasaki‑Tanaka R, Totsuka M, Honda M, Masuzaki R, Matsumoto N, Ogawa M, Takahashi M, Okamoto H, Okamoto H, et al: Severe hepatitis E virus genotype 3b in a patient with alcohol‑associated liver disease: A case report. Med Int 4: 22, 2024
APA
Kanda, T., Arima, S., Sasaki‑Tanaka, R., Totsuka, M., Honda, M., Masuzaki, R. ... Kogure, H. (2024). Severe hepatitis E virus genotype 3b in a patient with alcohol‑associated liver disease: A case report. Medicine International, 4, 22. https://doi.org/10.3892/mi.2024.146
MLA
Kanda, T., Arima, S., Sasaki‑Tanaka, R., Totsuka, M., Honda, M., Masuzaki, R., Matsumoto, N., Ogawa, M., Takahashi, M., Okamoto, H., Kogure, H."Severe hepatitis E virus genotype 3b in a patient with alcohol‑associated liver disease: A case report". Medicine International 4.3 (2024): 22.
Chicago
Kanda, T., Arima, S., Sasaki‑Tanaka, R., Totsuka, M., Honda, M., Masuzaki, R., Matsumoto, N., Ogawa, M., Takahashi, M., Okamoto, H., Kogure, H."Severe hepatitis E virus genotype 3b in a patient with alcohol‑associated liver disease: A case report". Medicine International 4, no. 3 (2024): 22. https://doi.org/10.3892/mi.2024.146