Open Access

Research advances of MAL family members in tumorigenesis and tumor progression (Review)

  • Authors:
    • Mengyao Li
    • Yan Du
    • Xianzhuo Zhang
    • Wence Zhou
  • View Affiliations

  • Published online on: February 14, 2024     https://doi.org/10.3892/mmr.2024.13181
  • Article Number: 57
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The myelin and lymphocyte protein (MAL) family is a novel gene family first identified and characterized in 2002. This family is comprised of seven members, including MAL, MAL2, plasmolipin, MALL, myeloid differentiation‑associated marker (MYADM), MYADML2 and CMTM8, which are located on different chromosomes. In addition to exhibiting extensive activity during transcytosis, the MAL family plays a vital role in the neurological, digestive, respiratory, genitourinary and other physiological systems. Furthermore, the intimate association between MAL and the pathogenesis, progression and metastasis of malignancies, attributable to several mechanisms such as DNA methylation has also been elucidated. In the present review, an overview of the structural and functional properties of the MAL family and the latest research findings regarding the relationship between several MAL members and various cancers is provided. Furthermore, the potential clinical and scientific significance of MAL is discussed and directions for future research are summarized.
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April-2024
Volume 29 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li M, Du Y, Zhang X and Zhou W: Research advances of MAL family members in tumorigenesis and tumor progression (Review). Mol Med Rep 29: 57, 2024
APA
Li, M., Du, Y., Zhang, X., & Zhou, W. (2024). Research advances of MAL family members in tumorigenesis and tumor progression (Review). Molecular Medicine Reports, 29, 57. https://doi.org/10.3892/mmr.2024.13181
MLA
Li, M., Du, Y., Zhang, X., Zhou, W."Research advances of MAL family members in tumorigenesis and tumor progression (Review)". Molecular Medicine Reports 29.4 (2024): 57.
Chicago
Li, M., Du, Y., Zhang, X., Zhou, W."Research advances of MAL family members in tumorigenesis and tumor progression (Review)". Molecular Medicine Reports 29, no. 4 (2024): 57. https://doi.org/10.3892/mmr.2024.13181