Open Access

Apolipoprotein A-1 downregulation promotes basal-like breast cancer cell proliferation and migration associated with DNA methylation

  • Authors:
    • Cong Wang
    • Shiliang Chen
    • Ranran Zhang
    • Mengqing Chen
    • Xiaoxiao Yang
    • Yibo He
    • Zuifei Shangguan
    • Qifen Mao
    • Zhezhong Zhang
    • Sunke Ying
  • View Affiliations

  • Published online on: May 1, 2024     https://doi.org/10.3892/ol.2024.14428
  • Article Number: 295
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Apolipoprotein A-I (APOA1) performs different roles in different subtypes of breast cancer. It is hypothesized to function as a tumor suppressor in basal-like breast cancer (BLBC). However, the specific role of APOA1 in BLBC and its underlying mechanisms remain unknown. The findings of the present study demonstrated a positive correlation between the expression level of APOA1 and the overall survival of patients with BLBC. Ectopic expression of APOA1 effectively inhibits the proliferation and metastasis of BLBC cells in vitro, and these effects are closely related to DNA methylation. To the best of our knowledge, the present study is the first to report increased methylation of the promoter region and decreased methylation of the structural genes of APOA1 in BLBC cells. These alterations resulted in the downregulation of APOA1 expression and suppression of BLBC tumor growth. Collectively, the results of the present study suggested that APOA1 mRNA expression is negatively regulated by DNA methylation in BLBC. Therefore, low expression of APOA1 may be a potential risk biomarker to predict survival in patients with BLBC.
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July-2024
Volume 28 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang C, Chen S, Zhang R, Chen M, Yang X, He Y, Shangguan Z, Mao Q, Zhang Z, Ying S, Ying S, et al: Apolipoprotein A-1 downregulation promotes basal-like breast cancer cell proliferation and migration associated with DNA methylation. Oncol Lett 28: 295, 2024
APA
Wang, C., Chen, S., Zhang, R., Chen, M., Yang, X., He, Y. ... Ying, S. (2024). Apolipoprotein A-1 downregulation promotes basal-like breast cancer cell proliferation and migration associated with DNA methylation. Oncology Letters, 28, 295. https://doi.org/10.3892/ol.2024.14428
MLA
Wang, C., Chen, S., Zhang, R., Chen, M., Yang, X., He, Y., Shangguan, Z., Mao, Q., Zhang, Z., Ying, S."Apolipoprotein A-1 downregulation promotes basal-like breast cancer cell proliferation and migration associated with DNA methylation". Oncology Letters 28.1 (2024): 295.
Chicago
Wang, C., Chen, S., Zhang, R., Chen, M., Yang, X., He, Y., Shangguan, Z., Mao, Q., Zhang, Z., Ying, S."Apolipoprotein A-1 downregulation promotes basal-like breast cancer cell proliferation and migration associated with DNA methylation". Oncology Letters 28, no. 1 (2024): 295. https://doi.org/10.3892/ol.2024.14428