Open Access

LPCAT1 promotes melanoma cell proliferation via Akt signaling

  • Authors:
    • Yuqian Wang
    • Yingjian Huang
    • Yan Wang
    • Wen Zhang
    • Ning Wang
    • Ruimin Bai
    • Ruiting Luo
    • Huihui Tuo
    • Yan Zheng
  • View Affiliations

  • Published online on: March 26, 2024     https://doi.org/10.3892/or.2024.8726
  • Article Number: 67
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanoma is the most lethal type of skin cancer with an increasing cutaneous cancer‑related mortality rate worldwide. Despite therapeutic advances in targeted therapy and immunotherapy, the overall survival of patients with melanoma remains unsatisfactory. Thus, a further understanding of the pathogenesis of melanoma may aid towards the development of therapeutic strategies. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a key enzyme that converts lysophosphatidylcholine into phosphatidylcholine in lipid remodeling. In the present study, LPCAT1 was found to play a pro‑proliferative role in melanoma. Firstly, the expression of LPCAT1 was found to be upregulated in tissues from patients with melanoma compared with that in benign nevi. Subsequently, LPCAT1 knockdown was performed, utilizing short hairpin RNA, which induced melanoma cell cycle arrest at the G1/S transition and promoted cell death. Moreover, LPCAT1 facilitated melanoma cell growth in an Akt‑dependent manner. In summary, the results of the present study indicate that targeting LPCAT1 may impede cell proliferation by inhibiting Akt signaling, thus providing a promising therapeutic strategy for melanoma in clinical practice.
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May-2024
Volume 51 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Huang Y, Wang Y, Zhang W, Wang N, Bai R, Luo R, Tuo H and Zheng Y: LPCAT1 promotes melanoma cell proliferation via Akt signaling. Oncol Rep 51: 67, 2024
APA
Wang, Y., Huang, Y., Wang, Y., Zhang, W., Wang, N., Bai, R. ... Zheng, Y. (2024). LPCAT1 promotes melanoma cell proliferation via Akt signaling. Oncology Reports, 51, 67. https://doi.org/10.3892/or.2024.8726
MLA
Wang, Y., Huang, Y., Wang, Y., Zhang, W., Wang, N., Bai, R., Luo, R., Tuo, H., Zheng, Y."LPCAT1 promotes melanoma cell proliferation via Akt signaling". Oncology Reports 51.5 (2024): 67.
Chicago
Wang, Y., Huang, Y., Wang, Y., Zhang, W., Wang, N., Bai, R., Luo, R., Tuo, H., Zheng, Y."LPCAT1 promotes melanoma cell proliferation via Akt signaling". Oncology Reports 51, no. 5 (2024): 67. https://doi.org/10.3892/or.2024.8726